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1

Transforming Growth Factor α-Pseudomonas Exotoxin Fusion Protein Prolongs Survival of Nude Mice Bearing Tumor Xenografts

David C. Heimbrook, Steven M. Stirdivant, Janet D. Ahern, Nancy L. Balishin, Denis R. Patrick, Gwynneth M. Edwards, Deborah Defeo-Jones, David J. FitzGerald, Ira Pastan and Allen Oliff

Journal:

Proceedings of the National Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 965 KB

english, 1990

2

Synthesis and biological evaluation of unnatural canthine alkaloids

Craig W. Lindsley, Michael J. Bogusky, William H. Leister, Ray T. McClain, Ronald G. Robinson, Stanley F. Barnett, Deborah Defeo-Jones, Charles W. Ross III, George D. Hartman

Journal:

Tetrahedron Letters

Year:

2005

Language:

english

File:

PDF, 127 KB

english, 2005

3

The Synthesis of a Prodrug of Doxorubicin Designed to Provide Reduced Systemic Toxicity and Greater Target Efficacy

Garsky, Victor M., Lumma, Patricia K., Feng, Dong-Mei, Wai, Jenny, Ramjit, Harri G., Sardana, Mohinder K., Oliff, Allen, Jones, Raymond E., DeFeo-Jones, Deborah, Freidinger, Roger M.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 81 KB

english, 2001

4

ras-Related gene sequences identified and isolated from Saccharomyces cerevisiae

DeFeo-Jones, D., Scolnick, E. M., Koller, R., Dhar, R.

Journal:

Year:

1983

File:

PDF, 504 KB

1983

5

Transforming growth factor alpha-Pseudomonas exotoxin fusion protein prolongs survival of nude mice bearing tumor xenografts.

Heimbrook, D. C., Stirdivant, S. M., Ahern, J. D., Balishin, N. L., Patrick, D. R., Edwards, G. M., Defeo-Jones, D., FitzGerald, D. J., Pastan, I., Oliff, A.

Journal:

Proceedings of the National Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 981 KB

english, 1990

6

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

Defeo-Jones, Deborah, Huang, Pearl S., Jones, Raymond E., Haskell, Kathleen M., Vuocolo, Gerald A., Hanobik, Michelle G., Huber, Hans E., Oliff, Alien

Journal:

Year:

1991

File:

PDF, 637 KB

1991

7

Expression and characterization of ras mRNAs from Saccharomyces cerevisiae.

Temeles, G L, DeFeo-Jones, D, Tatchell, K, Ellinger, M S, Scolnick, E M

Journal:

Molecular and Cellular Biology

Year:

1984

Language:

english

File:

PDF, 1.92 MB

english, 1984

8

Saccharomyces cerevisiae synthesizes proteins related to the p21 gene product of ras genes found in mammals.

Papageorge, A G, Defeo-Jones, D, Robinson, P, Temeles, G, Scolnick, E M

Journal:

Molecular and Cellular Biology

Year:

1984

Language:

english

File:

PDF, 1.86 MB

english, 1984

9

Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors

Zhijian Zhao, William H. Leister, Ronald G. Robinson, Stanley F. Barnett, Deborah Defeo-Jones, Raymond E. Jones, George D. Hartman, Joel R. Huff, Hans E. Huber, Mark E. Duggan, Craig W. Lindsley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 123 KB

english, 2005

10

Assignment of three rat cellularRASoncogenes to chromosomes 1, 4, and X

Josiane Szpirer, Deborah Defeo-Jones, Ronald W. Ellis, Göran Levan, Claude Szpirer

Journal:

Somatic Cell and Molecular Genetics

Year:

1985

Language:

english

File:

PDF, 474 KB

english, 1985

11

Tumors secreting human TNF/cachectin induce cachexia in mice

Oliff, Allen, Defeo-Jones, Deborah, Boyer, Mark, Martinez, Douglas, Kiefer, David, Vuocolo, Gerald, Wolfe, Abigail, Socher, Susan H.

Journal:

Year:

1987

Language:

english

File:

PDF, 14.18 MB

english, 1987

12

Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors

John C. Hartnett, Stanley F. Barnett, Mark T. Bilodeau, Deborah Defeo-Jones, George D. Hartman, Hans E. Huber, Raymond E. Jones, Astrid M. Kral, Ronald G. Robinson, Zhicai Wu

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 138 KB

english, 2008

13

Breast Tumor Cells with PI3K Mutation or HER2 Amplification Are Selectively Addicted to Akt Signaling

She, Qing-Bai, Chandarlapaty, Sarat, Ye, Qing, Lobo, Jose, Haskell, Kathleen M., Leander, Karen R., DeFeo-Jones, Deborah, Huber, Hans E., Rosen, Neal, Ouchi, Toru

Journal:

Year:

2008

Language:

english

File:

PDF, 731 KB

english, 2008

14

The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activity

Tony Siu, Yiwei Li, Johnny Nagasawa, Jun Liang, Lida Tehrani, Peter Chua, Raymond E. Jones, Deborah Defeo-Jones, Stanley F. Barnett, Ronald G. Robinson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 208 KB

english, 2008

15

Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

Yiwei Li, Jun Liang, Tony Siu, Essa Hu, Michael A. Rossi, Stanley F. Barnett, Deborah Defeo-Jones, Raymond E. Jones, Ronald G. Robinson, Karen Leander, Hans E. Huber, Sachin Mittal, Nicholas Cosford,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 166 KB

english, 2009

16

Nucleotide sequence of two ras H related-genes isolated from the yeast Saccharomyces cerevisiae

Dhar, R., Nieto, A., Koller, R., Defeo-Jones, D., Scolnick, E.M.

Journal:

Nucleic Acids Research

Year:

1984

Language:

english

File:

PDF, 339 KB

english, 1984

17

Substitution of lysine for arginine at position 42 of human transforming growth factor-alpha eliminates biological activity without changing internal disulfide bonds.

Defeo-Jones, D, Tai, J Y, Vuocolo, G A, Wegrzyn, R J, Schofield, T L, Riemen, M W, Oliff, A

Journal:

Molecular and Cellular Biology

Year:

1989

Language:

english

File:

PDF, 619 KB

english, 1989

18

Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors

BARNETT, Stanley F., DEFEO-JONES, Deborah, FU, Sheng, HANCOCK, Paula J., HASKELL, Kathleen M., JONES, Raymond E., KAHANA, Jason A., KRAL, Astrid M., LEANDER, Karen, LEE, Ling L., MALINOWSKI, John, McA

Journal:

Biochemical Journal

Year:

2005

Language:

english

File:

PDF, 320 KB

english, 2005

19

Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity

Zhijian Zhao, Ronald G. Robinson, Stanley F. Barnett, Deborah Defeo-Jones, Raymond E. Jones, George D. Hartman, Hans E. Huber, Mark E. Duggan, Craig W. Lindsley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 214 KB

english, 2008

20

Comparison of the binding of the human papillomavirus type 16 and cottontail rabbit papillomavirus E7 proteins to the retinoblastoma gene product

Haskell, K. M., Vuocolo, G. A., Defeo-Jones, D., Jones, R. E., Ivey-Hoyle, M.

Journal:

Journal of General Virology

Year:

1993

Language:

english

File:

PDF, 1.19 MB

english, 1993

21

Epidermal growth factor receptor binding is affected by structural determinants in the toxin domain of transforming growth factor-alpha-Pseudomonas exotoxin fusion proteins.

Edwards, G M, DeFeo-Jones, D, Tai, J Y, Vuocolo, G A, Patrick, D R, Heimbrook, D C, Oliff, A

Journal:

Molecular and Cellular Biology

Year:

1989

Language:

english

File:

PDF, 1.51 MB

english, 1989

22

10.1038/81351

Jones, Raymond E., DeFeo-Jones, Deborah, Garsky, Victor M., Wong, Bradley K., Feng, Dong-Mei, Bolyar, Trina, Haskell, Kathleen, Kiefer, David M., Leander, Karen, McAvoy, Elizabeth, Lumma, Patricia, Wa

Journal:

Nature Medicine

Year:

2000

Language:

english

File:

PDF, 109 KB

english, 2000

23

Rapid assembly of diverse and potent allosteric Akt inhibitors

Zhicai Wu, Ronald G. Robinson, Sheng Fu, Stanley F. Barnett, Deborah Defeo-Jones, Raymond E. Jones, Astrid M. Kral, Hans E. Huber, Nancy E. Kohl, George D. Hartman, Mark T. Bilodeau

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 142 KB

english, 2008

24

Structure-function analysis of synthetic and recombinant derivatives of transforming growth factor alpha.

Defeo-Jones, D, Tai, J Y, Wegrzyn, R J, Vuocolo, G A, Baker, A E, Payne, L S, Garsky, V M, Oliff, A, Riemen, M W

Journal:

Molecular and Cellular Biology

Year:

1988

Language:

english

File:

PDF, 1.66 MB

english, 1988

25

[Methods in Enzymology] Peptide Growth Factors Part C Volume 198 || Molecular and biochemical approaches to structure-function analysis of transforming growth factor α

Defeo-Jones, Deborah

Year:

1991

Language:

english

File:

PDF, 1.14 MB

english, 1991

26

Biological activity of a transforming growth factor-alpha-Pseudomonasexotoxin fusion protein in vitro and in vivo

David C. Heimbrook, Steven M. Stirdivant, Janet D. Ahern, Nancy L. Balishin, Denis R. Patrick, Gwynneth M. Edwards, Deborah Defeo-Jones, David J. FitzGerald, Ira Pastan, Allen Oliff

Journal:

Journal of Industrial Microbiology & Biotechnology

Year:

1991

Language:

english

File:

PDF, 330 KB

english, 1991

27

Nucleotide sequence of the two rat cellular rasH genes.

Ruta, M, Wolford, R, Dhar, R, Defeo-Jones, D, Ellis, R W, Scolnick, E M

Journal:

Molecular and Cellular Biology

Year:

1986

Language:

english

File:

PDF, 1007 KB

english, 1986

28

Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors

Tony Siu, Jun Liang, Jeannie Arruda, Yiwei Li, Raymond E. Jones, Deborah Defeo-Jones, Stanley F. Barnett, Ronald G. Robinson

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 202 KB

english, 2008

29

Requirement of either of a pair of ras-related genes of Saccharomyces cerevisiae for spore viability

Tatchell, Kelly, Chaleff, Deborah T., DeFeo-Jones, Deborah, Scolnick, Edward M.

Journal:

Year:

1984

File:

PDF, 544 KB

1984

30

Design and Synthesis of a Pro-Drug of Vinblastine Targeted at Treatment of Prostate Cancer with Enhanced Efficacy and Reduced Systemic Toxicity

Brady, Stephen F., Pawluczyk, Joseph M., Lumma, Patricia K., Feng, Dong-Mei, Wai, Jenny M., Jones, Raymond, DeFeo-Jones, Deborah, Wong, Bradley K., Miller-Stein, Cynthia, Lin, Jiunn H., Oliff, Allen,

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 140 KB

english, 2002

31

Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product.

Stirdivant, S M, Huber, H E, Patrick, D R, Defeo-Jones, D, McAvoy, E M, Garsky, V M, Oliff, A, Heimbrook, D C

Journal:

Molecular and Cellular Biology

Year:

1992

Language:

english

File:

PDF, 2.75 MB

english, 1992

32

Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors

Craig W. Lindsley, Zhijian Zhao, William H. Leister, Ronald G. Robinson, Stanley F. Barnett, Deborah Defeo-Jones, Raymond E. Jones, George D. Hartman, Joel R. Huff, Hans E. Huber, Mark E. Duggan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 382 KB

english, 2005

33

Spontaneously Transformed NRK Cells Lose Their Mitogenic Response to Epidermal Growth Factor

Wegrzyn, Ronald J., Defeo-jones, Deborah, Heimbrook, David C., Wallen, John, Kiefer, David M., Riemen, Mark W., Oliff, Allen

Journal:

Year:

1989

Language:

english

File:

PDF, 1.09 MB

english, 1989

34

Lovastatin selectively inhibits ras activation of the 12-O-tetradecanoylphorbol-13-acetate response element in mammalian cells.

Defeo-Jones, D, McAvoy, E M, Jones, R E, Vuocolo, G A, Haskell, K M, Wegrzyn, R J, Oliff, A

Journal:

Molecular and Cellular Biology

Year:

1991

Language:

english

File:

PDF, 688 KB

english, 1991

35

Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.

Hu, Q J, Bautista, C, Edwards, G M, Defeo-Jones, D, Jones, R E, Harlow, E

Journal:

Molecular and Cellular Biology

Year:

1991

Language:

english

File:

PDF, 1.90 MB

english, 1991

36

Development of Pyridopyrimidines as Potent Akt1/2 Inhibitors

Zhicai Wu, John C. Hartnett, Lou Anne Neilson, Ronald G. Robinson, Sheng Fu, Stanley F. Barnett, Deborah Defeo-Jones, Raymond E. Jones, Astrid M. Kral, Hans E. Huber, George D. Hartman, Mark T. Bilode

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 148 KB

english, 2008

37

Androgen ablation augments human HLA2.1-restricted T cell responses to PSA self-antigen in transgenic mice

Mohamed S. Arredouani, Stephanie S. Tseng-Rogenski, Brent K. Hollenbeck, June Escara-Wilke, Karen R. Leander, Deborah Defeo-Jones, Clara Hwang, Martin G. Sanda

Journal:

Year:

2010

Language:

english

File:

PDF, 297 KB

english, 2010

38

Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model

Mark T. Bilodeau, Adrienne E. Balitza, Jacob M. Hoffman, Peter J. Manley, Stanley F. Barnett, Deborah Defeo-Jones, Kathleen Haskell, Raymond E. Jones, Karen Leander, Ronald G. Robinson, Anthony M. Smi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 146 KB

english, 2008

39

Mammalian and yeast ras gene products: biological function in their heterologous systems

DeFeo-Jones, D, Tatchell, K, Robinson, L., Sigal, I., Vass, W., Lowy, D., Scolnick, E.

Journal:

Year:

1985

Language:

english

File:

PDF, 1.74 MB

english, 1985

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